Mesenteric Lymph Nodes - Horse Anatomy | Inside The Equine
Lymphatic System

Mesenteric Lymph Nodes

Lymphonodi mesenterici

Overview

The mesenteric lymph nodes are a large group of nodes embedded within the mesentery; the peritoneal fold that suspends the intestines. They include the cranial mesenteric (draining the small intestine and large colon), caudal mesenteric (draining the small colon and rectum), and cecal lymph nodes. These nodes filter lymph draining from the entire gastrointestinal tract, making them the primary immunological surveillance system for the gut. They contain abundant lymphoid tissue and are the most common site of alimentary lymphosarcoma and metastatic strangles in horses.

Clinical Significance

The mesenteric lymph nodes are not directly accessible but can be assessed by rectal palpation (the mesenteric root is normally a soft, cord-like structure), transabdominal ultrasound, and abdominocentesis. Markedly enlarged mesenteric lymph nodes palpable per rectum suggest lymphosarcoma or bastard strangles. Normal mesenteric nodes are not individually palpable. Peritoneal fluid analysis may show neoplastic lymphocytes or degenerate neutrophils depending on the disease process.

Common Conditions & Injuries

Bastard Strangles (Metastatic Strangles)

Metastatic abscessation of internal lymph nodes by S. equi, most commonly the mesenteric lymph nodes. Occurs in approximately 2% of strangles cases, usually in horses with incomplete immunity. The mes

Alimentary Lymphosarcoma

The most common form of lymphosarcoma in horses, involving the mesenteric lymph nodes and intestinal wall (particularly the small intestine). Causes malabsorption and protein-losing enteropathy.

Rhodococcus equi; Abdominal Form

In foals, R. equi can cause mesenteric lymph node abscessation in addition to the more well-known pulmonary form. Affects foals 1-6 months of age.

Intestinal Granulomatous Disease

Chronic granulomatous inflammation of the intestinal wall and mesenteric lymph nodes. May be associated with Mycobacterium avium subsp. paratuberculosis (though true Johne's disease is very rare in ho

Frequently Asked Questions

What is Bastard Strangles (Metastatic Strangles) in horses?

Metastatic abscessation of internal lymph nodes by S. equi, most commonly the mesenteric lymph nodes. Occurs in approximately 2% of strangles cases, usually in horses with incomplete immunity. The mesenteric nodes may form large abscesses that cause colic or rupture into the abdomen. Signs include: Chronic weight loss; recurrent fever; intermittent colic; diarrhea; peritonitis if abscess ruptures into abdomen; purpura hemorrhagica may develop simultaneously

What is Alimentary Lymphosarcoma in horses?

The most common form of lymphosarcoma in horses, involving the mesenteric lymph nodes and intestinal wall (particularly the small intestine). Causes malabsorption and protein-losing enteropathy. Signs include: Progressive weight loss despite normal or increased appetite; recurrent colic; diarrhea; ventral edema (hypoproteinemia); enlarged mesenteric lymph nodes palpable per rectum; thickened small intestinal wall on ultrasound

What is Rhodococcus equi; Abdominal Form in horses?

In foals, R. equi can cause mesenteric lymph node abscessation in addition to the more well-known pulmonary form. Affects foals 1-6 months of age. Signs include: Chronic diarrhea in foals; weight loss; pot-bellied appearance; abdominal lymphadenopathy visible on ultrasound; often concurrent with pulmonary disease (cough, nasal discharge)

What is Intestinal Granulomatous Disease in horses?

Chronic granulomatous inflammation of the intestinal wall and mesenteric lymph nodes. May be associated with Mycobacterium avium subsp. paratuberculosis (though true Johne's disease is very rare in horses) or idiopathic granulomatous enteritis. Signs include: Chronic weight loss; diarrhea; hypoproteinemia; thickened intestinal wall and enlarged mesenteric lymph nodes; poor response to treatment

What are the clinical concerns for the Mesenteric Lymph Nodes?

The mesenteric lymph nodes are not directly accessible but can be assessed by rectal palpation (the mesenteric root is normally a soft, cord-like structure), transabdominal ultrasound, and abdominocentesis. Markedly enlarged mesenteric lymph nodes palpable per rectum suggest lymphosarcoma or bastard strangles. Normal mesenteric nodes are not individually palpable. Peritoneal fluid analysis may show neoplastic lymphocytes or degenerate neutrophils depending on the disease process.

Explore This Structure in 3D

See the Mesenteric Lymph Nodes on our interactive 3D horse model. Open 3D Model