Anhidrosis (Non-Sweater Syndrome) in Horses

Anhidrosis (Non-Sweater Syndrome)

Overview

Inability to sweat adequately, most common in hot, humid climates. Affects 2–6% of horses in subtropical regions. The exact cause is unknown but involves desensitization or downregulation of sweat gland β2-adrenergic receptors due to chronic stimulation. Can be partial or complete. Potentially life-threatening due to inability to thermoregulate.

Signs & Symptoms

Absence of sweating or only patchy sweating under the mane/saddle area after exercise; elevated respiratory rate (>60 bpm) at rest to compensate for lost evaporative cooling; elevated rectal temperature (>103°F) that doesn't normalize; dry, flaky coat; alopecia of face; poor performance; may collapse with heat stroke if exercised in heat

Affected Structures

Frequently Asked Questions

What is Anhidrosis (Non-Sweater Syndrome) in horses?

Inability to sweat adequately, most common in hot, humid climates. Affects 2–6% of horses in subtropical regions. The exact cause is unknown but involves desensitization or downregulation of sweat gland β2-adrenergic receptors due to chronic stimulation. Can be partial or complete. Potentially life-threatening due to inability to thermoregulate.

What are the signs of Anhidrosis (Non-Sweater Syndrome)?

Absence of sweating or only patchy sweating under the mane/saddle area after exercise; elevated respiratory rate (>60 bpm) at rest to compensate for lost evaporative cooling; elevated rectal temperature (>103°F) that doesn't normalize; dry, flaky coat; alopecia of face; poor performance; may collapse with heat stroke if exercised in heat