Neuropathogenic strains of EHV-1 cause vasculitis in the CNS, leading to ischemic damage to the spinal cord and brain. The D752 mutation in the DNA polymerase gene is associated with neuropathogenicity.
Acute onset hindlimb ataxia and weakness following fever; urinary incontinence and bladder distension; perineal and tail hypalgesia; dog-sitting posture; may progress rapidly to recumbency; Fever followed 6-10 days later by acute hindlimb ataxia and weakness; urinary incontinence; perineal hypalgesia; may progress to recumbency; outbreaks common
Neuropathogenic strains of EHV-1 cause vasculitis in the CNS, leading to ischemic damage to the spinal cord and brain. The D752 mutation in the DNA polymerase gene is associated with neuropathogenicity.
Acute onset hindlimb ataxia and weakness following fever; urinary incontinence and bladder distension; perineal and tail hypalgesia; dog-sitting posture; may progress rapidly to recumbency; Fever followed 6-10 days later by acute hindlimb ataxia and weakness; urinary incontinence; perineal hypalgesia; may progress to recumbency; outbreaks common