## Overview Equine recurrent uveitis (ERU), also called moon blindness, is an immune-mediated inflammatory disease of the uveal tract and the leading cause of blindness in horses. It is characterized by repeated episodes of intraocular inflammation that progressively damage the eye. ## Causes Autoimmune response, often triggered by prior infection (Leptospira in some regions) or other ocular insults, in genetically susceptible horses. ## Diagnosis Clinical signs of active uveitis (squinting, tearing, cloudy eye, constricted pupil) recurring over time, plus secondary changes such as synechiae or cataract. ## Treatment Aggressive anti-inflammatory therapy during flares (topical and systemic). Long-term management may include cyclosporine implants or other immunomodulation. Enucleation for painful blind eyes. ## Recovery and Prognosis Guarded for vision. Many affected eyes eventually become blind despite treatment. Pain control is achievable. ## Prevention Prompt treatment of any uveitis episode. Leptospira control in endemic areas may reduce risk.
recurrent squinting, tearing, and light sensitivity; cloudy cornea; constricted pupil; progressive cataract or synechiae; eventual blindness
## Overview Equine recurrent uveitis (ERU), also called moon blindness, is an immune-mediated inflammatory disease of the uveal tract and the leading cause of blindness in horses. It is characterized by repeated episodes of intraocular inflammation that progressively damage the eye. ## Causes Autoimmune response, often triggered by prior infection (Leptospira in some regions) or other ocular insults, in genetically susceptible horses. ## Diagnosis Clinical signs of active uveitis (squinting, tearing, cloudy eye, constricted pupil) recurring over time, plus secondary changes such as synechiae or cataract. ## Treatment Aggressive anti-inflammatory therapy during flares (topical and systemic). Long-term management may include cyclosporine implants or other immunomodulation. Enucleation for painful blind eyes. ## Recovery and Prognosis Guarded for vision. Many affected eyes eventually become blind despite treatment. Pain control is achievable. ## Prevention Prompt treatment of any uveitis episode. Leptospira control in endemic areas may reduce risk.
recurrent squinting, tearing, and light sensitivity; cloudy cornea; constricted pupil; progressive cataract or synechiae; eventual blindness