## Overview Multicentric lymphosarcoma is the most common form of lymphoma in adult horses. Malignant lymphocytes involve multiple lymph-node groups and often internal organs. Signs include generalized lymph-node enlargement, weight loss, ventral edema, intermittent fever, anemia, and elevated globulins. ## Causes Neoplastic proliferation of lymphocytes. No specific cause is identified. ## Diagnosis Enlarged nodes on examination, cytology or biopsy showing a monomorphic lymphoid population, and staging with ultrasound or radiographs. ## Treatment Corticosteroids may produce temporary improvement. Chemotherapy protocols exist but responses are usually short-lived. Most care is palliative. ## Recovery and Prognosis Poor. Survival is typically weeks to a few months after diagnosis. ## Prevention None.
generalized peripheral lymphadenopathy; weight loss; ventral edema; intermittent fever; anemia; hyperglobulinemia
## Overview Multicentric lymphosarcoma is the most common form of lymphoma in adult horses. Malignant lymphocytes involve multiple lymph-node groups and often internal organs. Signs include generalized lymph-node enlargement, weight loss, ventral edema, intermittent fever, anemia, and elevated globulins. ## Causes Neoplastic proliferation of lymphocytes. No specific cause is identified. ## Diagnosis Enlarged nodes on examination, cytology or biopsy showing a monomorphic lymphoid population, and staging with ultrasound or radiographs. ## Treatment Corticosteroids may produce temporary improvement. Chemotherapy protocols exist but responses are usually short-lived. Most care is palliative. ## Recovery and Prognosis Poor. Survival is typically weeks to a few months after diagnosis. ## Prevention None.
generalized peripheral lymphadenopathy; weight loss; ventral edema; intermittent fever; anemia; hyperglobulinemia