The most common autoimmune skin disease of horses. Autoantibodies target desmoglein-1 in the intercellular bridges (desmosomes) of the superficial epidermis, causing acantholysis (cell separation). Can be triggered by medications, infections, or UV exposure. Requires immunosuppressive therapy and carries a guarded prognosis for complete remission.
Generalized crusting, scaling, and alopecia; starts on the face and limbs, then generalizes; characteristic annular crusts with peripheral collarettes; footpad coronary band crusting and pain; ventral edema; may have fever, depression, and weight loss; acantholytic cells on cytology are diagnostic; may wax and wane
The most common autoimmune skin disease of horses. Autoantibodies target desmoglein-1 in the intercellular bridges (desmosomes) of the superficial epidermis, causing acantholysis (cell separation). Can be triggered by medications, infections, or UV exposure. Requires immunosuppressive therapy and carries a guarded prognosis for complete remission.
Generalized crusting, scaling, and alopecia; starts on the face and limbs, then generalizes; characteristic annular crusts with peripheral collarettes; footpad coronary band crusting and pain; ventral edema; may have fever, depression, and weight loss; acantholytic cells on cytology are diagnostic; may wax and wane