Pemphigus Foliaceus in Horses | Inside The Equine

Pemphigus Foliaceus

Overview

The most common autoimmune skin disease of horses. Autoantibodies target desmoglein-1 in the intercellular bridges (desmosomes) of the superficial epidermis, causing acantholysis (cell separation). Can be triggered by medications, infections, or UV exposure. Requires immunosuppressive therapy and carries a guarded prognosis for complete remission.

Signs & Symptoms

Generalized crusting, scaling, and alopecia; starts on the face and limbs, then generalizes; characteristic annular crusts with peripheral collarettes; footpad coronary band crusting and pain; ventral edema; may have fever, depression, and weight loss; acantholytic cells on cytology are diagnostic; may wax and wane

Affected Structures

Frequently Asked Questions

What is Pemphigus Foliaceus in horses?

The most common autoimmune skin disease of horses. Autoantibodies target desmoglein-1 in the intercellular bridges (desmosomes) of the superficial epidermis, causing acantholysis (cell separation). Can be triggered by medications, infections, or UV exposure. Requires immunosuppressive therapy and carries a guarded prognosis for complete remission.

What are the signs of Pemphigus Foliaceus?

Generalized crusting, scaling, and alopecia; starts on the face and limbs, then generalizes; characteristic annular crusts with peripheral collarettes; footpad coronary band crusting and pain; ventral edema; may have fever, depression, and weight loss; acantholytic cells on cytology are diagnostic; may wax and wane