Lethal autosomal recessive disorder in Arabian foals causing complete absence of functional T and B lymphocytes due to a DNA-PKcs gene mutation. The thymus is hypoplastic and lacks lymphocytes.
Recurrent infections starting at 2-5 months (when maternal antibodies wane); pneumonia (often adenoviral or Pneumocystis); diarrhea; failure to thrive; death by 5 months; no response to antimicrobial treatment
Lethal autosomal recessive disorder in Arabian foals causing complete absence of functional T and B lymphocytes due to a DNA-PKcs gene mutation. The thymus is hypoplastic and lacks lymphocytes.
Recurrent infections starting at 2-5 months (when maternal antibodies wane); pneumonia (often adenoviral or Pneumocystis); diarrhea; failure to thrive; death by 5 months; no response to antimicrobial treatment