Severe Combined Immunodeficiency (SCID) in Horses

Severe Combined Immunodeficiency (SCID)

Overview

Lethal autosomal recessive disorder in Arabian foals causing complete absence of functional T and B lymphocytes due to a DNA-PKcs gene mutation. The thymus is hypoplastic and lacks lymphocytes.

Signs & Symptoms

Recurrent infections starting at 2-5 months (when maternal antibodies wane); pneumonia (often adenoviral or Pneumocystis); diarrhea; failure to thrive; death by 5 months; no response to antimicrobial treatment

Affected Structures

Frequently Asked Questions

What is Severe Combined Immunodeficiency (SCID) in horses?

Lethal autosomal recessive disorder in Arabian foals causing complete absence of functional T and B lymphocytes due to a DNA-PKcs gene mutation. The thymus is hypoplastic and lacks lymphocytes.

What are the signs of Severe Combined Immunodeficiency (SCID)?

Recurrent infections starting at 2-5 months (when maternal antibodies wane); pneumonia (often adenoviral or Pneumocystis); diarrhea; failure to thrive; death by 5 months; no response to antimicrobial treatment