Liver - Horse Anatomy | Inside The Equine
Digestive System

Liver

Hepar

Overview

The equine liver weighs approximately 5 kg (about 1% of body weight) and lies primarily on the right side of the abdomen, tucked against the diaphragm. Unlike many species, the horse has no gallbladder; bile is produced continuously and drains directly into the duodenum. The liver performs over 500 metabolic functions including bile production, protein synthesis, glycogen storage, detoxification, and bilirubin metabolism. It receives dual blood supply from the hepatic artery (oxygenated) and the portal vein (nutrient-rich blood from the GI tract).

Clinical Significance

The equine liver lacks a gallbladder; bile drains continuously into the duodenum via the hepatic and common bile ducts. Liver enzymes (GGT, SDH, AST, ALP) and bile acids are key diagnostic markers. The liver has remarkable regenerative capacity; clinical signs may not appear until >70% of hepatic function is lost. Ultrasound is valuable for assessing liver size and echogenicity.

Common Conditions & Injuries

Hepatic Lipidosis

Fatty infiltration of the liver, often secondary to negative energy balance.

Pyrrolizidine Alkaloid Toxicity

Chronic liver damage caused by ingestion of plants containing pyrrolizidine alkaloids (e.g., Senecio spp., Crotalaria, Echium). Megalocytosis and biliary fibrosis are characteristic histopathological

Theiler's Disease (Serum Hepatitis)

Acute hepatic necrosis associated with administration of equine-origin biological products.

Cholangiohepatitis

Inflammation of the bile ducts and liver parenchyma.

Liver Abscess

Focal bacterial infection within the liver parenchyma.

Cholelithiasis

Formation of biliary calculi (gallstones) in the bile ducts. Uncommon but clinically significant when present.

Tyzzer's Disease

Acute fatal hepatitis in foals (1-6 weeks old) caused by Clostridium piliforme. Characterized by focal hepatic necrosis with intracellular filamentous bacteria.

Frequently Asked Questions

What is Hepatic Lipidosis in horses?

Fatty infiltration of the liver, often secondary to negative energy balance. Signs include: Inappetence; weight loss; jaundice; depression; elevated liver enzymes

What is Pyrrolizidine Alkaloid Toxicity in horses?

Chronic liver damage caused by ingestion of plants containing pyrrolizidine alkaloids (e.g., Senecio spp., Crotalaria, Echium). Megalocytosis and biliary fibrosis are characteristic histopathological findings. Signs include: Weight loss; jaundice; photosensitization; neurological signs (hepatic encephalopathy); often fatal; photosensitization (unpigmented skin); icterus; hepatic encephalopathy (head pressing, aimless wandering, yawning); diarrhea

What is Theiler's Disease (Serum Hepatitis) in horses?

Acute hepatic necrosis associated with administration of equine-origin biological products. Signs include: Acute onset depression; jaundice; hepatic encephalopathy; head pressing; high mortality

What is Cholangiohepatitis in horses?

Inflammation of the bile ducts and liver parenchyma. Signs include: Fever; jaundice; colic; weight loss; elevated GGT and bilirubin

What is Liver Abscess in horses?

Focal bacterial infection within the liver parenchyma. Signs include: Intermittent fever; weight loss; colic; elevated fibrinogen; detected on ultrasound

What is Cholelithiasis in horses?

Formation of biliary calculi (gallstones) in the bile ducts. Uncommon but clinically significant when present. Signs include: Recurrent colic; weight loss; intermittent fever; icterus; elevated liver enzymes (GGT, ALP)

What is Tyzzer's Disease in horses?

Acute fatal hepatitis in foals (1-6 weeks old) caused by Clostridium piliforme. Characterized by focal hepatic necrosis with intracellular filamentous bacteria. Signs include: Peracute death in foals; profound depression; fever; icterus; diarrhea; convulsions

What are the clinical concerns for the Liver?

The equine liver lacks a gallbladder; bile drains continuously into the duodenum via the hepatic and common bile ducts. Liver enzymes (GGT, SDH, AST, ALP) and bile acids are key diagnostic markers. The liver has remarkable regenerative capacity; clinical signs may not appear until >70% of hepatic function is lost. Ultrasound is valuable for assessing liver size and echogenicity.

Explore This Structure in 3D

See the Liver on our interactive 3D horse model. Open 3D Model