Pyrrolizidine Alkaloid Toxicity in Horses

Pyrrolizidine Alkaloid Toxicity

Overview

Chronic liver damage caused by ingestion of plants containing pyrrolizidine alkaloids (e.g., Senecio spp., Crotalaria, Echium). Megalocytosis and biliary fibrosis are characteristic histopathological findings.

Signs & Symptoms

Weight loss; jaundice; photosensitization; neurological signs (hepatic encephalopathy); often fatal; photosensitization (unpigmented skin); icterus; hepatic encephalopathy (head pressing, aimless wandering, yawning); diarrhea

Affected Structures

Frequently Asked Questions

What is Pyrrolizidine Alkaloid Toxicity in horses?

Chronic liver damage caused by ingestion of plants containing pyrrolizidine alkaloids (e.g., Senecio spp., Crotalaria, Echium). Megalocytosis and biliary fibrosis are characteristic histopathological findings.

What are the signs of Pyrrolizidine Alkaloid Toxicity?

Weight loss; jaundice; photosensitization; neurological signs (hepatic encephalopathy); often fatal; photosensitization (unpigmented skin); icterus; hepatic encephalopathy (head pressing, aimless wandering, yawning); diarrhea